NGFN-PLUS
Molecular mechanisms in obesity
Coordinator: | Prof. Dr. Johannes Hebebrand | |
Institution: | Klinik für Psychiatrie und -psychotherapie des Kindes- und Jugendalters, LVR Klinikum, Universität Duisburg-Essen | |
Homepage: | www.uni-due.de/rke-kj |
Major goal of the network “Molecular mechanisms in obesity” was the identification of genes/alleles predisposing to obesity and their subsequent evaluation in epidemiological, developmental, clinical, functional and therapeutic terms.
The extension and subsequent maintenance of our successful research pipeline (figure 1) established during NGFN1&2 was vital for the network. Using GWAS (genome wide association studies) data–novel polygenes were identified (Workblock (WB) 1, SP1: “Gene identification”); studies in rodents were continued (SP2). As a third and new approach, we included the subproject “Proteomics” in workblock 1 (SP3). We validated the respective findings and assessed the relevance of detected alleles in relationship to different developmental stages in epidemiological samples in workblock 2 (Epidemiology). Functional studies in workblock 3 focused on the implications of the detected genetic variation using in vitro and in vivo models. The analysis of Fto knock out mice facilitated the analysis of the obesity polygene with the largest effect size currently known (SP10). Within workblock 4 “Therapy” we initiated systemic studies using in vivo models to examine negative side effects of therapeutically induced weight loss at the molecular level (SP12), compound screening for novel obesity genes (SP11) as well as studies on the impact of obesity genes on diet and behavior in childhood and adolescence in a mouse model (SP14).
Latest results can be found in detail in the descriptions of the subprojects
Deputy Coordinator: Prof. Dr. Anke Hinney
The extension and subsequent maintenance of our successful research pipeline (figure 1) established during NGFN1&2 was vital for the network. Using GWAS (genome wide association studies) data–novel polygenes were identified (Workblock (WB) 1, SP1: “Gene identification”); studies in rodents were continued (SP2). As a third and new approach, we included the subproject “Proteomics” in workblock 1 (SP3). We validated the respective findings and assessed the relevance of detected alleles in relationship to different developmental stages in epidemiological samples in workblock 2 (Epidemiology). Functional studies in workblock 3 focused on the implications of the detected genetic variation using in vitro and in vivo models. The analysis of Fto knock out mice facilitated the analysis of the obesity polygene with the largest effect size currently known (SP10). Within workblock 4 “Therapy” we initiated systemic studies using in vivo models to examine negative side effects of therapeutically induced weight loss at the molecular level (SP12), compound screening for novel obesity genes (SP11) as well as studies on the impact of obesity genes on diet and behavior in childhood and adolescence in a mouse model (SP14).
Latest results can be found in detail in the descriptions of the subprojects
Deputy Coordinator: Prof. Dr. Anke Hinney
- TP1 Identification of human obesity genes with a focus on developmental aspects
- TP2 Identification and characterization of obesity genes, gene-gene and diet gene interactions involved in polygenic obesity in mice
- TP3 Alterations of the mouse brain proteome associated with the early development of diet-induced obesity in the mouse
- TP WB2 Evaluation of candidate genes for obesity and related disorders
- TP WB3 Novel mouse models for the evaluation of candidate genes in the physiology of energy balance regulation
- TP10 Investigation of Fto as a major contributor to obesity
- TP11 Systematic molecular characterisation of compounds for prevention and therapy of obesity and insulin resistance
- TP12 Weight cycling does not affect longevity in two different mouse strains
- TP14 Implications of diet and exercise with interaction of allelic variations in the Berlin Fat Mouse line
- TP15 Central statistical genomics and data management
- TP16 Coordination and quality management
- Publications
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CURRENT
NGFN-MEETING-2012
NGFN- MEETING
NGFN1&2
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