NGFN-PLUS
Environment-related diseases
Coordinator: | Prof. Dr. Stefan Schreiber | |
Institution: | Institut für Klinische Molekularbiologie | |
Homepage: | www.ikmb.uni-kiel.de |
The barriers of the body are the crucial interaction point for host defense of a complex organism against its environment. Most of the human barrier organs can be effected by chronic inflammatory disorders. From genetic etiology but also from epidemiological studies it has become clear that chronic inflammatory diseases of barrier organs are caused by a polygenic susceptibility. Nevertheless, environmental trigger factors, that reside in the lifestyle of modern industrialized civilizations, are important causes for the manifestation of disease in genetically susceptible individuals. In the network different groups have joined in their efforts to uncover the polygenic susceptibility of environment-related diseases of barrier organs. The projects are interlinked with the wish to also define general inflammation susceptibility genes and to reach conclusive understanding of a disease driven systems biology, independent of the effected organ. With strong translational efforts pathophysiological pathways are discovered that offer novel targets for future intervention, be it for therapy or for the prevention of manifestation of disease. With access to the large German population-representative biobank “popgen“ the groups can use control populations and also infrastructure to generate quality controlled follow up of their patient populations.
Latest results can be found in detail in the descriptions of the subprojects.
Latest results can be found in detail in the descriptions of the subprojects.
- GP1 - GP7 Identification of genetic susceptibility loci for Crohn\'s disease, ulcerative colitis, and primary sclerosing cholangitis
- GP2 Genetic determinants of Asthma and Allergy
- GP4 Pulmonary tuberculosis: Gene discovery and functional analysis
- GP5 Genetic etiology of atopic dermatitis
- GP6 genetic etiology of psoriasis
- GP9 Functional Annotation of Candidate Disease Genes
- GP10 Pathways & Gene Networks: Innate immunity and barrier function
- TP1 Quality Management
- TP2 Genetic Epidemiology
- TP3 Bioinformatics Support
- TP7 Coordination
- Publications
KTT
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CURRENT
NGFN-MEETING-2012
NGFN- MEETING
NGFN1&2
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